Method for selecting cell

A method for selecting a cell, comprising the following first step and second step:

• a first step:
• measuring the expression level of a protein encoded by at least one gene selected from genes comprising any one of the base sequences represented by SEQ ID NOS:
• 1 to 16 or orthologous genes thereof;
• and
• a second step:
• comparing the expression level of the protein encoded by the gene measured in the first step with a control value of the expression level of the protein encoded by the gene in a control cell, and evaluating the expression level capable of suppressing reduction of a recombinant protein based on a difference therebetween.

A method for selecting a cell, comprising the following first step and second step:

• a first step:
• measuring the expression level of a gene in a cell, the gene being at least one gene selected from genes comprising any one of the base sequences represented by SEQ ID NOS:
• 1 to 16 or orthologous genes thereof;
• and
• a second step:
• calculating and comparing a relative expression level and selecting a cell according to the following procedures (a) to (d);
• (a) calculating a relative quantitative value by dividing the expression level of the gene in a test cell measured in the first step by the expression level of a standard gene in the test cell
• a relative quantitative value=(the expression level of the gene in a test cell measured in the first step)/(the expression level of a standard gene),
• (b) calculating a control value by dividing the expression level of the gene in a control cell by the expression level of the standard gene in the control cell
• a control value=(the expression level of the gene in a control cell)/(the expression level of the standard gene),
• (c) calculating a relative expression level by dividing the relative quantitative value for the test cell calculated in (a) by the control value calculated in (b)
• a relative expression level=[the relative quantitative value for the test cell calculated in (a)]/[the control value calculated in (b)], and
• (d) comparing the relative quantitative values calculated in (a) or the relative expression level calculated in (c) among the respective test cells, and thereby selecting a cell in which each value is high or low.