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US 2019/0316091 A1Published application
Erythroid cells comprising arginase
AssigneeRubius Therapeutics, Inc.
InventorsAvak Kahvejian, Jordi Mata-Fink, John Round, David Arthur Berry, Noubar B. Afeyan
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Abstract
Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith.
Claims30
An enucleated erythroid cell comprising an exogenous polypeptide comprising arginase or a functional fragment thereof,
- wherein the enucleated erythroid cell is made by a process comprising introducing into an erythroid cell precursor a nucleic acid encoding the exogenous polypeptide.
A nucleated erythroid cell precursor comprising an exogenous polypeptide comprising arginase or a functional fragment thereof,
- wherein the nucleated erythroid cell precursor was made by a process comprising introducing an exogenous nucleic acid encoding the exogenous polypeptide into the nucleated erythroid cell precursor.
Dependencies are inferred from the claim text.