Antigen presenting scaffolds for immune-cell manipulation
AssigneeDanmarks Tekniske Universitet
InventorsSine Reker Hadrup, Vibeke Mindahl Rafa, Søren Nyboe Jakobsen
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Abstract
The present invention relates to artificial antigen presenting cell (aAPC) scaffolds to provide cells with specific functional stimulation to obtain phenotypic and functional properties ideal to mediate tumor regression or viral clearance. In particular, the scaffolds of the present invention comprise antigens, such as peptide-MHC (pMHC) class I molecules, and specific combinations of cytokines and co-stimulatory molecules to allow effective expansion and functional stimulation of specific T cells.
Claims21
An artificial antigen presenting cell (aAPC) scaffold comprising a polymeric backbone to which are attached the following template molecules:
- i. at least two different gamma-chain receptor cytokines selected from the group consisting of IL-21, IL-2, IL-15, IL-4, IL-9 and IL-7,
- ii. at least one antigen,
- iii. optionally, at least one co-stimulatory molecule selected from the group consisting of B7.2 (CD86), B7.1 (CD80), CD40, ICOS and
- PD-L1, and
- iv. optionally, at least one CD47 molecule.
2-50. (canceled)
Dependencies are inferred from the claim text.