Antibodies to olanzapine and use thereof

An isolated antibody or a binding fragment thereof, which binds to olanzapine, comprising:

• a) a light chain variable region having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:11 and a heavy chain variable region having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:12;
• b) a light chain variable region having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:15 and a heavy chain variable region having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:16;
• c) a light chain variable region having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:31 and a heavy chain variable region having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:32;
• d) a light chain variable region having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:35 and a heavy chain variable region having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:36;
• or
• e) a light chain variable region having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:39 and a heavy chain variable region having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:40, and
• wherein the antibody comprises the CDR1, CDR2, and CDR3 regions of the light chain variable region and the CDR1, CDR2, and CDR3 regions of the heavy chain variable region.