US 2019/0315870 A1 · ANTIBODIES AGAINST MICA AND/OR MICB AND USES THEREOF

Abstract

The disclosure provides antibodies that specifically bind human MICA/B and methods of use thereof. In some aspects, the disclosure is directed to methods of treating a cancer in a subject, comprising administering to the subject an anti-MICA/B antibody.

Claims30

Dependent claims

An antibody that specifically binds to human MHC class I polypeptide-related sequence A (MICA) and/or human MEW class I polypeptide-related sequence B (MICB), comprising a heavy chain variable region (VH) and a light chain variable region (VL);

wherein the VH comprises a VH complementarity determining region (CDR) 1, a VH-CDR2, and a VH-CDR3 and the VL comprises a VL-CDR1, a VL-CDR2, and a VL-CDR3;
wherein the VH-CDR3 comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:
7, 17, 27, 37, and 47.

Dependencies are inferred from the claim text.

Antibodies against mica and/or micb and uses thereof

Life of this patent

Antibodies against mica and/or micb and uses thereof

Life of this patent

Abstract

Claims30