Therapeutic and diagnostic methods for cancer
AssigneeHoffmann-La Roche Inc.
InventorsChristian Klein, Laura Codarri Deak
Life of this patent
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Abstract
The present invention provides therapeutic and diagnostic methods and compositions for cancer and for enhancing immune function in an individual having cancer. The invention provides methods of treatment, methods for determining whether an individual suffering from a cancer is responding to treatment comprising a PD-1 axis binding antagonist, predicting responsiveness of an individual suffering from a cancer to treatment comprising a PD-1 axis binding antagonist, and methods of selecting a therapy for an individual suffering from cancer.
Claims18
1-53. (canceled)
A method for treating an individual suffering from a cancer, the method comprising administering an effective amount of a PD-1 axis binding antagonist to the individual, wherein the ratio between Granzyme B+ CD4+ T cells and FOXP3+ CD4+ T cells in a blood sample obtained from the individual has been determined to be 1 or greater.
55-61. (canceled)
Dependencies are inferred from the claim text.