Antibodies That Bind Human Cannabinoid 1 (CB1) Receptor

An isolated antibody or antigen binding fragment thereof, comprising

• a heavy chain comprising a CDR1 amino acid sequence of SEQ ID NO:
• 352, a CDR2 amino acid sequence of SEQ ID NO:
• 353, and a CDR3 amino acid sequence of SEQ ID NO:
• 354, wherein heavy chain CDR1, CDR2 and CDR3 may collectively comprise one or two amino acid substitutions;
• and
• a light chain comprising a CDR1 amino acid sequence of SEQ ID NO:
• 355, a CDR2 amino acid sequence of SEQ ID NO:
• 356, and a CDR3 amino acid sequence of SEQ ID NO:
• 357, wherein light chain CDR1, CDR2 and CDR3 may collectively comprise one or two amino acid substitutions,
• wherein the antibody or fragment binds a conformational epitope of human cannabinoid receptor 1 (CB1) receptor comprising the glutamic acid (E) and histidine (H) residues of ECL2 of the human CB1 receptor which are absent from ECL2 of the mouse CB1 receptor.

The isolated antibody or antigen binding fragment thereof that binds to cannabinoid receptor 1 (CB1), wherein the antibody or antigen binding fragment thereof comprises one or two of the following:

• a light chain CDR1 comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
• 626-661;
• a light chain CDR2 comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
• 662-742, and
• a light chain CDR3 comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
• 742-824.