Antibodies to il-15
AssigneeCalypso Biotech SA
InventorsALAIN VICARI, OLIVIER LEGER
Life of this patent
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Abstract
The present invention relates to antibodies binding IL-15, in particular humanized antibodies. In particular, the anti-IL-15 antibodies according to the invention are able to neutralize IL-15 activity and are useful in the prevention and/or treatment of an autoimmune disease and/or inflammatory disorder, a malignancy, transplant rejection, metabolic condition and/or an infectious disease caused by parasitic, viral or bacterial pathogens.
Claims15
A method of preventing and/or treating an IL-15 related disease or disorder comprising administering in a subject in need thereof a therapeutically effective amount of an antibody or antigen-binding fragment thereof comprising:
- (1) a heavy chain variable region of SEQ ID NO:
- 5 or any variant thereof wherein 1, 2, 3, 4, 5, 6, 7, 8, or 9 amino acids of said sequence are substituted by a different amino acid, and
- (2) a light chain variable region of SEQ ID NO:
- 24 or any variant thereof wherein 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 amino acids of said sequence are substituted by a different amino acid,
- or an antigen-binding fragment thereof;
- or a pharmaceutical composition thereof.
Dependencies are inferred from the claim text.