Antibodies recognizing alpha-synuclein

The nucleic acid of claim 38, wherein the antibody comprises three Kabat CDRs of SEQ ID NOS:

• 10-12 respectively and three Kabat CDRs of SEQ ID NOS:
• 25-27 respectively.

(canceled)

24-25. (canceled)

The nucleic acid of claim 38, wherein the antibody comprising a mature heavy chain variable region having an amino acid sequence at least 95% identical to H4 (SEQ ID NO:

• 17) and a mature light chain variable region at least 95% identical to L3 (SEQ ID NO:
• 31).

The nucleic acid of claim 38 encoding the mature heavy chain variable region is fused to a heavy chain constant region and the mature light chain variable region fused to a light chain constant region.

(canceled)

The nucleic acid of claim 38, wherein the mature heavy chain variable region has an amino acid sequence designated H4 (SEQ ID NO:

• 17) and the mature light chain variable region has an amino acid sequence designated L3 (SEQ ID NO:
• 31).

The nucleic acid of claim 18, wherein the mature heavy chain variable region has an amino acid sequence designated H5 (SEQ ID NO:

• 18) and the mature light chain variable region has an amino acid sequence designated L3 (SEQ ID NO:
• 31).

35-37. (canceled)

A nucleic acid encoding the heavy and/or light chain(s) of an antibody comprising a mature heavy chain variable region comprising three CDRs of SEQ ID NO:17 and having an amino acid sequence at least 90% identical to SEQ ID NO:

• 17 and a mature light chain variable region comprising three CDRs of SEQ ID NO:31 and having an amino acid sequence at least 90% identical to SEQ ID NO:31, wherein the antibody specifically binds to human alpha synuclein.

41-56. (canceled)

First and second vectors respectively comprising nucleic acids encoding a mature heavy chain variable region and a mature light chain variable region, each operably linked to one or more regulatory sequences to effect expression an antibody comprising a mature heavy chain variable region comprising three CDRs of SEQ ID NO:17 and having an amino acid sequence at least 90% identical to SEQ ID NO:17 and a mature light chain variable region comprising three CDRs of SEQ ID NO:31 and having an amino acid sequence at least 90% identical to SEQ ID NO:31, wherein the antibody specifically binds to human alpha synuclein.