Inhibitors of complement factor h
AssigneeDuke University
InventorsEdward F. Patz, Jr., Michael J. Campa, Elizabeth Gottlin, Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody
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Abstract
Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.
Claims21
An isolated antibody or antibody fragment thereof capable of binding to a reduce form of Complement Factor H (CFH) protein
An isolated antibody or antibody fragment thereof capable of binding to complement factor H (CFH) protein.
An isolated antibody or antibody fragment thereof which immunospecifically binds to Complement Factor H (CFH) protein, wherein the binding of the antibody or antibody fragment to CFH protein is sensitive to the reduced form of CFH protein.
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Dependencies are inferred from the claim text.