Dengue virus-like particle, antibody against dengue virus, and composition comprising the same
AssigneeDay-Yu CHAO
InventorDay-Yu CHAO
Life of this patent
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Abstract
The present invention is related to a Dengue virus-like particle. Said Dengue virus-like particle exhibits almost-cut pr-M junction and is particularly suitable for producing antibody that recognizes all four types of Dengue virus. The present invention also provides antibody obtained by using said virus-like particle and composition comprising the same.
Claims20
An expression vector, encoding a virus-like particle having a membrane protein;
- wherein said membrane protein comprises a pr-M junction of RUXRKKVVMT at its pre-cleaved form;
- wherein said U is K or R, and said X is S or A.
A virus-like particle, comprising a membrane protein;
- wherein said membrane protein comprises a pr-M junction of RUXRKKVVMT at its pre-cleaved form;
- wherein said U is K or R, and said X is S or A.
An isolated anti-dengue virus antibody or an antigen-binding portion thereof comprising:
- at least one of a heavy chain complementarity determining region 1 (H-CDR1) comprising GYTFTEYT (SEQ ID NO:
- 19),
- at least one of a heavy chain complementarity determining region 2 (H-CDR2) comprising INPNNGGTT (SEQ ID NO:
- 20),
- at least one of a heavy chain complementarity determining region 3 (H-CDR3) comprising VRYGGYYVFDY (SEQ ID NO:
- 21),
- at least one of a light chain complementarity determining region 1 (L-CDR1) comprising KSVSTSGYSY (SEQ ID NO:
- 22),
- at least one of a light chain complementarity determining region 2 (L-CDR2) comprising LVS (SEQ ID NO:
- 23), and
- at least one of a light chain complementarity determining region 3 (L-CDR3) comprising QHIRELTRR (SEQ ID NO:
- 24).
An isolated anti-dengue virus antibody or an antigen-binding portion thereof comprising:
- at least one of a heavy chain complementarity determining region 1 (H-CDR1) comprising GYSITSDY (SEQ ID NO:
- 27),
- at least one of a heavy chain complementarity determining region 2 (H-CDR2) comprising ISYSGST (SEQ ID NO:
- 28),
- at least one of a heavy chain complementarity determining region 3 (H-CDR3) comprising ARSLLPNWYFD (SEQ ID NO:
- 29),
- at least one of a light chain complementarity determining region 1 (L-CDR1) comprising KSVSTSGYSY (SEQ ID NO:
- 30),
- at least one of a light chain complementarity determining region 2 (L-CDR2) comprising LVS (SEQ ID NO:
- 31), and
- at least one of a light chain complementarity determining region 3 (L-CDR3) comprising QHIRELTRS (SEQ ID NO:
- 32).
-29. (canceled)
Dependencies are inferred from the claim text.