Compositions and methods of chimeric autoantibody receptor t cells
AssigneeThe Trustees of the University of Pennsylvania
InventorsAimee S. Payne, Christoph T. Ellebrecht, Vijay Bhoj, Michael C. Milone
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Abstract
The invention includes compositions comprising at least one chimeric autoantibody receptor (CAAR) specific for an autoantibody, vectors comprising the same, compositions comprising CAAR vectors packaged in viral particles, and recombinant T cells comprising the CAAR. The invention also includes methods of making a genetically modified T cell expressing a CAAR (CAART) wherein the expressed CAAR comprises a desmoglein extracellular domain.
Claims22
-43. (canceled)
An isolated nucleic acid encoding a chimeric receptor comprising an extracellular domain comprising Dsg1, Dsg3, or a fragment thereof that binds an autoantibody expressed on a B-cell, and a transmembrane domain, wherein the chimeric receptor, when present on the surface of a cell, binds the autoantibody expressed on the B-cell or induces killing of the B-cell expressing the autoantibody.
Dependencies are inferred from the claim text.