Compositions and methods for treatment of type 1 diabetes
AssigneeTolerion, Inc.
InventorsBart O. Roep, William H. Robinson, Paul Utz, Hideki Garren, Lawrence Steinman
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Abstract
The present invention provides compositions and methods for treating insulin-dependent diabetes mellitus in a subject comprising administration of a self-vector encoding and expressing human proinsulin.
Claims27
1-9. (canceled)
A method of treating or preventing insulin-dependent diabetes mellitus (IDDM) in a subject comprising administering to the subject a vector in an amount sufficient to achieve a reduction in the frequency of CD8+ T cells reactive to proinsulin.
A method of treating or preventing insulin-dependent diabetes mellitus (IDDM) in a subject comprising administering to the subject a vector in an amount sufficient to achieve an increase in C-peptide.
A method of administering to a subject having or at risk of developing IDDM a vector in an amount sufficient to achieve a reduction in the frequency of CD8+ T cells reactive to proinsulin.
Dependencies are inferred from the claim text.