Small cationic anti-biofilm and idr peptides
AssigneeThe University of British Columbia
InventorsRobert E.W. Hancock, Cesar de la Fuente Nunez, Jason Kindrachuk, Havard Jenssen, Joerg Overhage, Evan Haney
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Abstract
The present invention relates generally to peptides and more specifically to anti-biofilm and immunomodulatory peptides.
Claims20
An isolated antibiofilm or immunomodulatory peptide having 7 to 12 amino acids, wherein the peptide has an amino acid sequence of SEQ ID NOS:
- 1-663, or analogs, derivatives, enantiomers, amidated and unamidated variations and conservative variations thereof.
A polypeptide X 1-A-X2 or a functional variant or mimetic thereof, wherein A represents at least one peptide having an amino acid sequence of SEQ ID NOS:
- 1-749 or analogs, derivatives, enantiomers, amidated and unamidated variations and conservative variations thereof;
- and wherein each X1 and X2 independently of one another represents any amino acid sequence of n amino acids, n varying from 0 to 50, and n being identical or different in X1 and X2.
A method of inhibiting the growth of bacterial biofilms comprising contacting a bacterial biofilm with an inhibiting effective amount of:
- (i) a peptide having an amino acid sequence of SEQ ID NOS:
- 1-749, or any combination thereof, or analogs, derivatives, enantiomers, amidated and unamidated variations and conservative variations thereof, and/or
- ii) an isolated anti-biofilm polypeptide X1-A-X2, or a functional variant or mimetic thereof, wherein A represents at least one peptide having an amino acid sequence of SEQ ID NOS:
- 1-749 or analogs, derivatives, enantiomers, amidated and unamidated variations and conservative variations thereof, each X1 and X2 independently of one another represents any amino acid sequence of n amino acids, n varying from 0 to 5, and n being identical or different in X1 and X2.
The method of claim 93, wherein the peptide is bound to a solid support or surface.
An isolated molecule that has anti-biofilm activity by virtue of inhibiting (p)ppGpp synthesis or causing (p)ppGpp degradation.
Dependencies are inferred from the claim text.