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US 2019/0315805 A1Published application
Targeted noninvasive imaging probes of egfr expressing cells
AssigneeCase Western Reserve University
InventorsJames P. Basilion, Richard Agnes
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Abstract
A probe for imaging EGFR expressing cells includes an EGFR targeting moiety, a reporter moiety, and a hydrophilic linker that links the EGFR targeting moiety to the reporter moiety. The hydrophilic linker enhances solubility of the probe in an aqueous media as well as binding affinity of the probe to EGFR expressing cells.
Claims20
A probe for imaging EGFR expressing cells, comprising:
- an EGFR targeting moiety,
- a reporter moiety, and
- a hydrophilic linker that links the EGFR targeting moiety to the reporter moiety, the hydrophilic linker enhancing solubility of the probe in an aqueous media as well as binding affinity of the probe to EGFR expressing cells.
A probe for imaging EGFR expressing cells, comprising:
- a hydrophobic EGFR targeting moiety,
- a reporter moiety, and
- a hydrophilic linker that links the hydrophobic EGFR targeting moiety to the reporter moiety, the hydrophilic linker enhancing solubility of the probe in an aqueous media as well as binding affinity of the probe to EGFR expressing cells.
A probe for imaging EGFR expressing cells, comprising:
- a hydrophobic EGFR targeting moiety that includes a peptide having SEQ ID NO:
- 1 or SEQ ID NO:
- 2,
- a fluorochrome reporter moiety, and
- a hydrophilic linker that links the hydrophobic EGFR targeting moiety to the reporter moiety, the hydrophilic linker enhancing solubility of the probe in an aqueous media as well as binding affinity of the probe to EGFR expressing cells.
2 more elements
Dependencies are inferred from the claim text.