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US 2019/0315769 A1Published application
Tetracyclic heterocycle compounds useful as hiv integrase inhibitors
AssigneeMerck Sharp & Dohme Corp.
InventorsThomas H. Graham, Tao Yu, Yonglian Zhang, John A. McCauley
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Abstract
The present invention relates to Tetracyclic Heterocycle Compounds of Formula and pharmaceutically acceptable salts or prodrug thereof, wherein A, X, R1, R2, R3 and R7 are as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Heterocycle Compound, and methods of using the Tetracyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
Claims15
A pharmaceutical composition comprising a compound having the structure:
- or a pharmaceutically acceptable salt thereof, doravirine and a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising a compound having the structure:
- or a pharmaceutically acceptable salt thereof, 4′-ethynyl-2-fluoro-2′-deoxyadenosine and a pharmaceutically acceptable carrier.
15. (canceled)
Dependencies are inferred from the claim text.