Heterocyclic compounds as rsv inhibitors

A compound represented by Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• is optionally substituted aryl or optionally substituted heteroaryl;
• is aryl or heteroaryl, which, when possible, is optionally substituted with one or more substituents which are not R2;
• X is O, S or NR4, and Y is N or CR5;
• or X is N or CR5, and Y is O, S or NR4;
• One Z is CR3, the other Zs are each independently selected from N and CR3;
• Each R1 selected from the group consisting of:
• halogen, hydroxyl, protected hydroxyl, amino, protected amino, optionally substituted —C1-C8 alkyl, and optionally substituted —C1-C8 alkoxy;
• Each R2 is selected from the group consisting of:
• 1) halogen;
• 2) optionally substituted —C1-C8 alkoxy;
• 3) optionally substituted —C1-C8 alkyl;
• 4) optionally substituted —C2-C8 alkenyl;
• 5) optionally substituted —C2-C8 alkynyl;
• 6) optionally substituted —C3-C12 cycloalkyl;
• 7) optionally substituted —C3-C12 cycloalkenyl;
• 8) optionally substituted 3- to 12-membered heterocycloalkyl;
• 9) optionally substituted aryl;
• 10) optionally substituted heteroaryl;
• 11) optionally substituted arylalkyl;
• 12) optionally substituted aryloxy;
• 13) —C(O)R12;
• 14) —C(O)NR13R14;
• 15) —C(O)NR11S(O)2R12;
• 16) —S(O)2NR13R14;
• 17) —NR13R14;
• 18) —NR11S(O)2R12;
• 19) —NR11C(O)R12;
• 20) —NR11C(O)NR13R14;
• and
• 21) —NR11C(O)NHS(O)2R12;
• n is 0, 1, 2, 3 or 4;
• m is 0, 1, 2, or 3;
• R3 is selected from the group consisting of:
• hydrogen, halogen, cyano, nitro, hydroxyl, protected hydroxyl, amino, protected amino, optionally substituted —C1-C8 alkyl, and optionally substituted —C1-C8 alkoxy;
• R4 is hydrogen or optionally substituted —C1-C8 alkyl;
• R5 is hydrogen, halogen, optionally substituted —C1-C8 alkyl, or optionally substituted —C1-C8 alkoxy;
• R12 at each occurrence is independently selected from the group consisting of:
• 1) Hydrogen;
• 2) Halogen;
• 3) Hydroxyl;
• 4) optionally substituted —C1-C8 alkoxy;
• 5) optionally substituted —C1-C8 alkyl;
• 6) optionally substituted —C2-C8 alkenyl;
• 7) optionally substituted —C2-C8 alkynyl;
• 8) optionally substituted —C3-C8 cycloalkyl;
• 9) optionally substituted —C3-C8 cycloalkenyl;
• 10) optionally substituted 3- to 8-membered heterocycloalkyl;
• 11) optionally substituted aryl;
• 12) optionally substituted arylalkyl;
• 13) optionally substituted heteroaryl;
• and
• 14) optionally substituted heteroarylalkyl;
• R11, R13 and R14 are each independently selected from hydrogen, optionally substituted —C1-C8-alkyl, optionally substituted —C2-C8-alkenyl, optionally substituted —C2-C8-alkynyl;
• optionally substituted —C3-C8-cycloalkyl, optionally substituted 3- to 8-membered heterocyclic, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, and optionally substituted heteroarylalkyl;
• alternatively, R13 and R14 are taken together with the nitrogen atom they attached to form a heterocyclic ring.