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US 2019/0315758 A1Published application
Compound used as bruton's tyrosine kinase inhibitor and preparation method and application thereof
AssigneesChengdu Brilliant Pharmaceutical Co., Ltd., Chengdu Highbred Pharmaceutical Co., Ltd.
InventorsYingfu Li, Haoxi Huang, Guanfeng Liu, Tonghui Chen, Junfeng Ren, Zhonghai Su
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Abstract
The present invention provides a compound having a structure shown in formula (I) or an isomer, pharmaceutically acceptable solvate, or salt thereof. The compound is used as a Bruton's tyrosine kinase inhibitor, and has a higher inhibitory activity against BTK and less adverse effects.
Claims20
A compound, having the structure shown in formula (I) or an isomer, a pharmaceutically acceptable solvate or salt thereof:
- wherein, Y is selected from substituted or unsubstituted aryls or heteroaryls;
- R is selected from substituted or unsubstituted alkenyls or alkynyls;
- M is selected from substituted or unsubstituted N-containing spirocyclic group or N-containing bridged-ring group, and the N atom is attached to a carbonyl group;
- or M is selected from the group shown in formula (II), A is a substituted or unsubstituted spirocyclic group or bridged-ring group, and the amino group is attached to a carbonyl group;
1 more element
Dependencies are inferred from the claim text.