US 2019/0315746 A1 · RUTAECARPINE ANALOGS AND APPLICATIONS THEREOF

Abstract

The present invention provides RUT analogs with various biological activities. In particular, the biological activities comprise anti-inflammatory activity, vasodilator effects, migration/invasion-suppressive activities, ability against damage due to remodeling between the epithelium and endothelium, collagen deposition and cardiac fibrosis suppress. Snail protein inhibitory effect, etc., which may improve cardiac, vasodilation, and lung functions. The RUT analogs disclosed herein also exhibit a lower cytotoxicity comparing to RUT.

Claims17

Dependent claims

A compound having the following Formula (I),

wherein R represents H or methoxy;
R1 and R2 are each independently selected from H, hydroxyl, halogen, C1-3 alkyl and C1-3 alkoxy;
R3, R4, and R5 are each independently selected from H, hydroxyl, fluoro, C1-3 alkyl and C1-3 alkoxy;
or a solvate, prodrug, stereoisomer, enantiomer, or pharmaceutically acceptable salt thereof.

1 more element

Dependencies are inferred from the claim text.

Rutaecarpine analogs and applications thereof

Life of this patent

Rutaecarpine analogs and applications thereof

Life of this patent

Abstract

Claims17