6-(buta-1,3-diyn-1-yl)benzo[d]thiazole derivatives

A compound of formula I

• wherein M is the group (4-hydroxypiperidin-1-yl)carbonyloxymethyl, (3-hydroxyazetidin-1-yl)carbonyloxymethyl or 1-(methylamino)cyclopropyl, or M represents one of the groups MA, MB, MC, MD, ME and MF represented below
• wherein
• XA1 represents methyl-d, methyl-d2, (C1-C4)alkyl, ω-(C2-C3)haloalkyl, ω-hydroxy(C2-C4)alkyl, 2,3-dihydroxyprop-1-yl, 3-hydroxy-2-(hydroxymethyl)prop-1-yl, oxetan-3-yl, (oxetan-3-yl)methyl, thietan-3-yl, 1,1-dioxidothietan-3-yl, (C3-C6)cycloalkyl, 3-hydroxycyclobut-1-yl, 3-(ω-hydroxy(C1-C3)alkyl)cyclobut-1-yl, tetrahydropyran-4-yl, (C3-C6)cycloalkyl(C1-C3)alkyl or ω-phosphonooxy-(C2-C4)alkyl;
• XA21 and XA22 each independently represent H, (C1-C4)alkyl, (C1-C3)haloalkyl or hydroxy(C1-C3)alkyl;
• XA3 represents H, (C1-C3)alkyl or halogen;
• XB1 represents (C1-C4)alkyl, ω-hydroxy(C2-C3)alkyl, (C3-C6)cycloalkyl, oxetan-3-yl or tetrahydropyran-4-yl;
• XB21 and XB22 each independently represent H, (C1-C4)alkyl, (C1-C3)haloalkyl or hydroxy(C1-C3)alkyl;
• XB31 and XB32 each independently represent H, halogen, hydroxy, (C1-C4)alkyl, (C1-C3)haloalkyl or hydroxy(C1-C3)alkyl;
• XB4 represents H, halogen, hydroxy or (C1-C3)alkyl;
• XC1 represents H, (C1-C4)alkyl, (C3-C6)cycloalkyl, ω-hydroxy(C2-C3)alkyl, oxetan-3-yl or tetrahydropyran-4-yl;
• XC2 represents H, (C1-C4)alkyl, (C1-C3)haloalkyl or hydroxy(C1-C3)alkyl;
• XC3 represents H, halogen (especially fluorine), hydroxy, (C1-C4)alkyl, (C1-C3)haloalkyl or hydroxy(C1-C3)alkyl;
• XC4 represents H, (C1-C3)alkyl, halogen or hydroxy;
• XD1 represents H, (C1-C4)alkyl, ω-(C2-C3)haloalkyl or ω-hydroxy(C2-C4)alkyl;
• XD2 and XD3 each independently represent H, (C1-C4)alkyl, (C1-C3)haloalkyl or hydroxy(C1-C3)alkyl;
• XE1 represents H, (C1-C4)alkyl, (C1-C3)haloalkyl, 1,2-dihydroxyethyl or hydroxy(C1-C3)alkyl;
• XF1 represents H, (C1-C4)alkyl, (C1-C3)haloalkyl, 1,2-dihydroxyethyl or hydroxy(C1-C3)alkyl;
• and
• one of V or W represents —O—, —CH(OH)— or —CH2—, and the other represents —CH2—;
• R1 represents H, PO3H2, SO3H, phosphonooxymethyl or the group L represented below
• wherein R2 represents (C1-C4)alkylamino(C1-C4)alkyl, [di(C1-C4)alkylamino](C1-C4)alkyl, phosphonooxy(C1-C4)alkyl, phosphonooxymethoxy, 2-(phosphonooxy-(C1-C4)alkyl)-phenyl, (2-(phosphonooxy)-phenyl)-(C1-C4)alkyl (especially 2-(2-(phosphonooxy)-phenyl)-ethyl) or [2-(phosphonooxy-(C1-C4)alkyl)-phenyl]-(C1-C4)alkyl;
• or a salt thereof.