Multi-substituted pyrimidine derivatives with excellent kinase inhibitory activities

A novel pyrimidine derivative compound represented by the following Formula 1, a stereoisomer thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof:

• wherein
• R1 and R2 are each independently a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a C1-C6 haloalkyl group, —O—(C1-C6 alkyl), —O—(C1-C6 haloalkyl), —C(O)—(C1-C6 alkyl), —C(O)—O—(C1-C6 alkyl) or —O—C(O)—(C1-C6 alkyl), or R1 and R2 are bonded together to form a 5-membered to 6-membered saturated or unsaturated ring, or R1 and R2 are bonded together to form a 5-membered to 6-membered saturated or unsaturated heteroring including one to four heteroatoms selected from nitrogen (N) and oxygen (O) atoms;
• Het is a C6-C15 aryl group, a 5-membered to 14-membered heteraryl group including one to four heteroatoms selected from nitrogen (N), oxygen (O) and sulfur (S) atoms, or a 5-membered to 6-membered heterocyclic group including one or two heteroatoms selected from nitrogen (N) and oxygen (O) atoms;
• A is a carbon (C) or nitrogen (N) atom;
• and
• B is a C6-C15 aryl group, a 5-membered to 14-membered heteraryl group including one to four heteroatoms selected from nitrogen (N), oxygen (O) and sulfur (S) atoms, or a 5-membered to 6-membered heterocyclic group including one or two heteroatoms selected from nitrogen (N) and oxygen (O) atoms.