Heteroaryl compounds and their use as mer inhibitors

A compound of formula (I):

• or a pharmaceutically acceptable salt thereof,
• wherein:
• Ring A is
• X is —C(═O)O—, —C(═O)N(R8)—, —C(═O)N(R8)CH2—, —SO2N(R8)—, —N(R8)—, —O—, or —S—;
• n is 1 or 2;
• p is 1, 2, or 3;
• L is none, C1-3 alkyl, C2-3 alkenyl, C1-3 alkyl-O—, C1-3 alkyl-O—C1-3alkyl, —C(═O)—, —C(═O)—C(═O)—, —C(═O)O—, —C(═O)N(R8)—, —C(═S)N(R8)—(CR12R13)m—, —C(═S)—, —C(═S)O—, —SO2—, —SO2—(CH2)m—, —(CR12R13)m—C(═O)—(CR12R13)m—, —C(═O)O(CR12R13)m—, —C(═O)—CR12═CR13—, or —CHR14;
• R1 is H, halogen, C1-3 alkyl, —NH(R8), —OR8 or —(CH2)—NR12R13;
• R2 is —Br, —Cl, —CN, cycloalkenyl, C2-6 alkenyl, aryl, biaryl, heteroaryl, heterobiaryl, heterocycle, C1-2 alkylaryl, C1-2 alkylheteroaryl, or C1-2 alkylheterocycle, which aryl, biaryl, heteroaryl, heterobiaryl, or heterocycle may optionally be substituted with one or more R18;
• R3 is halogen, cycloalkyl, cycloalkenyl, aryl, biaryl, heteroaryl, heterobiaryl, or heterocycle which cycloalkyl, cycloalkenyl, aryl, biaryl, heteroaryl, heterobiaryl, or heterocycle, may optionally be substituted with one or more R9;
• R4, R5, R6, and R7 are the same as or different from each other, and are each independently H, halogen, C1-3 alkyl, —OR21;
• —OCH2R21;
• —C(═O)NHR21, —C(═O)OR21, —C(═O)SR21;
• —C(═O)S—SR21, —CH2OR21, or —CH2NHR21;
• R8 is H, C1-6 alkyl, C1-3 alkylaryl, or C1-3 alkylheteroaryl which C1-6 alkyl, C1-3 alkylaryl or C1-3 alkylheteroaryl may optionally be substituted with one or more R9;
• when R1 is —NH(R8)— and X is —C(═O)N(R8)—, the R8 groups together may be —CH2—, forming a ring with the nitrogen atoms to which they are attached;
• R9 is halogen, hydroxyl, —CN, —NO2, —CHO, —COOH, —(C═O)H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 aminoalkyl, C3-10 cycloalkyl, C1-6 haloalkyl, C1-4 hydroxyalkyl, C1-6 alkoxy, cycloalkenyl, aryl, heterocycle, heteroaryl, —NR10R11, -J9-NR10R11, -J9-COOR8, -J9-alkyl, -J9-C3-10 cycloalkyl, -J9-cycloalkenyl, -J9-heterocycle, -J9-heteroaryl, or -J9-aryl, which alkyl, C1-6 alkoxy, C3-10 cycloalkyl, heterocycle, heteroaryl, aryl, -J9-alkyl, -J9-C3-10 cycloalky, -J9-heterocycle, -J9-heteroaryl, or -J9-aryl, may be substituted with one or more R16;
• R10 and R11 each independently is H, C1-6 alkyl, C3-10 cycloalkyl or SO2R8;
• R12 and R13 each independently is H, C1-6 alkyl, or C3-10 cycloalkyl;
• R12 and R13 together with the carbon atom to which they are attached may form a C3-6 cycloalkyl;
• R14 is —C(═O)NHR15, —C(═O)OR15, —CH2OR15, or —CH2NHR15;
• R15 is H, or C1-3 alkyl;
• R16 is halogen, hydroxyl, —CN, —CHO, —NR10R11, —NO2, C1-6 alkyl, (═O), C3-10 cycloalkyl, C1-4 hydroxyalkyl, C1-6 alkoxy, C2-6 alkenyl, aryl, heterocycle, -J16-alkyl, -J16-aryl, -J16-heterocycle, —(CH2)l—NR10R11, —(CH2)l—COOR8, or —(CH2)l—C(═O)—NR10R11, which -J16-heterocycle may be substituted with one or more R17;
• R17 is C1-6 alkyl, C1-4 hydroxyalkyl, or C1-4 aminoalkyl;
• R18 is halogen, hydroxyl, —CN, —NO2, —CHO, —COOH, —(C═O)H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 aminoalkyl, C3-10 cycloalkyl, C1-6 haloalkyl, C1-4 hydroxyalkyl, C1-6 alkoxy, cycloalkenyl, aryl, heterocycle, heteroaryl, —NR10R11, -J18-NR10R11, -J18-COOR, -J18-alkyl, -J18-C3-10 cycloalkyl, -J18-cycloalkenyl, -J18-heterocycle, -J18-heteroaryl, or -J18-aryl, which alkyl, C1-6 alkoxy, C3-10 cycloalkyl, heterocycle, heteroaryl, aryl, -J18-alkyl, -J18-C3-10 cycloalky, -J18-heterocycle, -J18-heteroaryl, or -J18-aryl may be substituted with one or more R19;
• R19 is halogen, hydroxyl, —CN, —CHO, —NR10R11, —NO2, C1-6 alkyl, (═O), C3-10 cycloalkyl, C1-4 hydroxyalkyl, C1-6 alkoxy, C2-6 alkenyl, aryl, heterocycle, -J19-alkyl, -J19-aryl, -J19-heterocycle, —(CH2)l—NR10R11, —(CH2)l—COOR8, or —(CH2)l—C(═O)—NR10R11, which -J19-heterocycle may be substituted with one or more R20;
• R20 is —NO2, C1-6 alkyl, C1-4 hydroxyalkyl, or C1-4 aminoalkyl;
• R21 is H, halogen, C1-6 alkyl, cycloalkyl, cycloalkenyl, aryl, biaryl, heteroaryl, heterobiaryl, or heterocycle which cycloalkyl, cycloalkenyl, aryl, biaryl, heteroaryl, heterobiaryl, or heterocycle, may optionally be substituted with one or more R22;
• R22 is halogen, hydroxyl, —CN, —NO2, —CHO, —COOH, —(C═O)H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 aminoalkyl, C3-10 cycloalkyl, C1-6 haloalkyl, C1-4 hydroxyalkyl, C1-6 alkoxy, cycloalkenyl, aryl, heterocycle, heteroaryl, —NR10R11, -J22-NR10R11, J22-COOR8, -J22-alkyl, -J22-C3-10 cycloalkyl, -J22-cycloalkenyl, -J22-heterocycle, -J22-heteroaryl, or -J22-aryl, which alkyl, C1-6 alkoxy, C3-10 cycloalkyl, heterocycle, heteroaryl, aryl, -J22-alkyl, -J22-C3-10 cycloalkyl, -J22-heterocycle, -J22-heteroaryl, or -J22-aryl, may be substituted with one or more R23;
• R23 is C1-6 alkyl;
• R24 is —CN, —(CH2)l—OR8, —(CH2)l—N(R8)2, or C1-3 alkyl;
• J9 is C1-3 alkyl, C1-3 alkyl-O—, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, —(CH2)l—C(═O)—(CH2)m—, —(CH2)l—CH═CH—C(═O)—(CH2)m—, —C(═O)O—, —(CH2)l—C(═O)NH—(CH2)m—, —(CH2)l—NHC(═O)—(CH2)m—, —(CR10R11)l—NR8—(CR10R11)m—, —NH—C(═O)—CR10R11—NH—C(═O)—, —NHC(═O)—, —O—, —O(C═O)—, —S—, —S(═O)—, —SO2—, or —NHSO2—;
• J16 is C1-3 alkyl, C1-3 alkyl-O—, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, —(CH2)l—C(═O)—(CH2)m—, —(CH2)l—CH═CH—C(═O)—(CH2)m—, —C(═O)O—, —(CH2)l—C(═O)NH—(CH2)m—, —(CH2)l—NHC(═O)—(CH2)m—, —(CR10R11)l—NR8—(CR10R11)m—, —NH—C(═O)—CR10R11—NH—C(═O)—, —NHC(═O)—, —O—, —O(C═O)—, —S—, —S(═O)—, or —SO2—;
• J18 is C1-3 alkyl, C1-3 alkyl-O—, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, —(CH2)l—C(═O)—(CH2)m—, —(CH2)l—CH═CH—C(═O)—(CH2)m—, —C(═O)—, —C(═O)O—, —(CH2)l—C(═O)NH—(CH2)m—, —(CH2)l—NHC(═O)—(CH2)m—, —(CR10R11)l—NR8—(CR10R11)m—, —NH—C(═O)—CR10R11—NH—C(═O)—, —NHC(═O)—, —O—, —O(C═O)—, —S—, —S(═O)—, —SO2—, or —NHSO2—;
• J19 is C1-3 alkyl, C1-3 alkyl-O—, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, —(CH2)l—C(═O)—(CH2)m—, (CH2)l—CH═CH—C(═CH2)m—, —C(═O)O—, —(CH2)l—C(═O)NH—(CH2)m—, —(CH2)l—NHC(═O)—(CH2)m—, —(CR10R11)l—NR8—(CR10R11)m—, —NH—C(═O)—CR10R11—NH—C(═O)—, —NHC(═O)—, —O—, —O(C═O)—, —S—, —S(═O)—, or —SO2—;
• J22 is C1-3 alkyl, C1-3 alkyl-O—, or —O—;
• and
• l and m each independently is an integer of 0 to 3;
• with the proviso that when Ring A is
• then
• R2 is not