Pd(II)-catalyzed Enantioselective Beta-Methylene C(sp3)–H Bond Activation

A compound that corresponds in structure to Formula A

• wherein:
• R3 is a C1-C4 alkyl group or a fluoro-substituted benzoyl group;
• the depicted cyclic moiety (Ring) on which R5 and R6 can be substituents is a cyclic ring structure containing one ring or two fused rings that each contains 5 or 6 atoms in the ring;
• Z is oxygen (O) or CH when part of a double bond;
• R5 and R6 are the same or different and are independently selected from the group consisting of a hydrido, halogen other than iodo, straight chain, branched chain and cyclic C1-C7 hydrocarbyl, C1-C7 hydrocarbyloxy, carboxy C1-C6 hydrocarbyl, trifluoromethyl, C1-C6 hydrocarboyl, nitro, C1-C6 hydrocarbylthiooxy, and a cyano group, or a benzyl group whose ring is substituted by 1 through five flouro groups;
• R7 is a straight chain, branched chain or cyclic C1-C7 hydrocarbyl group, or a C1-C7 hydrocarbyloxy group;
• “n” is zero or one, such that when n is zero, the carbon atom bearing R7 and R7 itself are absent, and the depicted Ring is bonded directly to the carbon atom bearing the R3C(O)HN group;
• R10 is a straight chain, branched chain or cyclic C1-C7 hydrocarbyl group, or a C1-C7 hydrocarbyloxy group that is unsubstituted, or R10 is an optionally substituted cyclic C5-C7 hydrocarbyl group, or an optionally substituted C5-C7 hydrocarbyloxy group whose optional substituent is one or two groups, R8 and R9, that are the same or different and are independently selected from the group consisting of straight chain, branched chain and cyclic C1-C7 hydrocarbyl group, and a C1-C7 hydrocarbyloxy group;
• and
• an atom with an adjacent asterisk is chiral.