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US 2019/0315703 A1Published application
Benzoheterocyclic alkylamine compounds and use thereof
AssigneesEast China University of Science and Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
InventorsJian LI, Lefu LAN, Baoli LI, Feifei CHEN, Shuaishuai NI, Yifu LIU, Hanwen WEI, Fei MAO, Jin ZHU
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Abstract
Disclosed are benzoheterocyclic alkylamine compounds, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, and a preparation method thereof, and use of the same in the manufacture of an antibacterial drug as an inhibitor of staphyloxanthin synthesis in Staphylococcus aureus.
Claims10
A compound of Formula I, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof:
- in the formula:
- X is S or O;
- R1 is H, a substituted or unsubstituted C1-C4 linear or branched alkyl;
- R2 is a substituted or unsubstituted C1-C3 linear alkyl, a substituted or unsubstituted C3-C8 cycloalkyl, a substituted or unsubstituted C2-C6 linear or branched alkenyl, —(CH═CH)-p, and a substituted or unsubstituted C2-C6 linear or branched alkynyl, wherein p is a positive integer from 2 to 5;
- R3 is a substituted or unsubstituted C1-C3 linear or branched alkyl, a substituted or unsubstituted C3-C8 cycloalkyl, a substituted or unsubstituted C3-C7 heteroaromatic ring group, and a substituted or unsubstituted C6-C10 aromatic ring group;
- n is an integer from 1 to 3;
- wherein, the group
- is located at position 2 or 3;
- wherein, in R1, R2, and R3, the substitution means having 1, 2, 3 or 4 substituents selected from the group consisting of a C1-C6 linear or branched alkyl, a C1-C6 haloalkyl, halogen, nitro, cyano, a C1-C4 linear or branched alkoxy, a —(C═O)—O—C1-C4 alkyl, a C6-C10 aromatic ring group, and a C3-C8 cycloalkyl.
6 more elements
Dependencies are inferred from the claim text.