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US 2019/0315700 A1Published application
Trpa1 and trpv4 inhibitors and methods of using the same for organ-specific inflammation and itch
AssigneeDuke University
InventorsWolfgang Liedtke, Farshid Guilak
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Abstract
Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. The methods may include administering to the subject an effective amount of a TRPA1 and/or TRPV4 inhibitor. Further provided are compositions including a TRPA1 and/or TRPV4 inhibitor compound in combination with a carrier, vehicle, or diluent that is suitable for topical application.
Claims16
A TRPV4 and TRPA1 inhibitor comprising a compound according to Formula I:
- wherein A, B, and C are independently selected from the group consisting of aromatic, heteroaromatic, cycloalkenyl, and heterocycloalkenyl groups;
- D is C1-C3 alkylene;
- E is a bond, or C1-C2 alkylene;
- and
- R is selected from the group consisting of hydrogen, hydroxyl, amino, alkyl, alkenyl, heteroalkyl, aromatic ring, or heteroaromatic ring.
2 more elements
Dependencies are inferred from the claim text.