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US 2019/0315677 A1Published application
3-carbon substituted 4-aminocyclopent-1-ene-1-carboxylic acid compounds as inhibitors of gamma-aminobutyric acid (gaba) aminotransferase
AssigneeNorthwestern University
InventorsRichard B. Silverman, Chi-Li Ni, Jose Juncosa
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Abstract
Disclosed are cyclopentene compounds for use as inhibitors of gamma-aminobutyric acid (GABA) aminotransferase (AT) and/or ornithine aminotransferase (OAT). The disclosed cyclopentene compounds include 3-carbon substituted 4-aminocyclopent-1-ene-carboxylic acid compounds which may be formulated in pharmaceutical composition for treating diseases and disorders associated with GABA-AT and/or OAT activity, including epilepsy, addiction, and hepatocellular carcinoma (HCC).
Claims27
A compound having a formula as follows or salts thereof:
- wherein:
- X is halo or hydroxyl;
- Y is amino, ammonio, or protected amino;
- wherein X and Y can have either R- or S-stereochemistry;
- and
- Z is carboxyl, carboxylate, or protected carboxyl.
3 more elements
Dependencies are inferred from the claim text.