Intravascular Membrane Oxygenator Catheter Systems and Methods

A method of intravascular oxygenation, the method comprising:

• a) introducing a catheter system to a region of interest in a subject, the catheter system comprising
• a catheter shaft having a tubular wall that extends from a proximal end to a distal end along a longitudinal axis to define a lumen;
• a plurality of hollow fiber membrane loops each having a proximal portion positioned within the lumen of the catheter shaft and a distal portion extending beyond the lumen of the catheter shaft;
• a pneumatic source in pneumatic communication with the plurality of hollow fiber membrane loops;
• the plurality of hollow fiber membrane loops are nonporous;
• and
• b) providing a gas containing oxygen at a pressure from the pneumatic source to the plurality of hollow fiber membrane loops, thereby creating a diffusive flux causing the gas containing oxygen to diffuse from an interior of the plurality of hollow fiber membrane loops to a fluid flowing past an exterior of the plurality of hollow fiber membrane loops in a region of interest of a subject, wherein the pressure is at least 1 pounds per square inch (PSI).