Biocompatible hydrogel and method for producing same
AssigneeSeoul National University R&Db Foundation
InventorsYoon Sik LEE, Byung Gee KIM, Sung Jun PARK, Sang Hyuk LEE
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Abstract
The present invention relates to a biopolymer-based hydrogel as a functional biomaterial produced by crosslinking in the presence of a photopolymerization initiator. The hydrogel of the present invention is elastic so as to be adapted to various shapes in both in vivo and in vitro applications. It is biocompatible, achieving maximum effects on wound healing as wound dressing and tissue adhesion preventing material. The present invention also relates to a method for producing the biocompatible hydrogel.
Claims18
A method for producing a biocompatible hydrogel, comprising:
- coupling a biopolymer with an amine group-containing phenolic compound to provide an amidated biopolymer;
- mixing the amidated biopolymer with a monophenolic compound and a tyrosine-based peptide represented by YY-X-YY (wherein each Y is a tyrosine residue and X is selected from 20 amino acid residues) to prepare a mixture solution;
- and mixing the mixture solution with a photopolymerization initiator, followed by photocuring to form a structure in which the amidated biopolymer molecules are bonded through a dityrosine linker.
A biocompatible hydrogel having a structure in which biopolymer molecules are coupled with an amine group-containing phenolic compound at both ends and are directly bonded through a dityrosine linker or are bonded through two or more dityrosine linkers connected via a tyrosine-based peptide moiety.
A biocompatible hydrogel having a structure in which a biopolymer molecule is coupled with an amine group-containing phenolic compound at one end and terminal functional groups introduced into another molecule of the biopolymer are connected to a dityrosine linker at the other end wherein the biopolymer molecules are directly bonded through a dityrosine linker or are bonded through one or more dityrosine linkers connected via a tyrosine-based peptide moiety.
Dependencies are inferred from the claim text.