Loading patent…
AssigneeLifeNet Health
InventorsSilvia Chen, Grant Cleavenger, Dennis Phelps, Evans Wralstad, Breanne Gjurich, Austin Johnson, Alana Sampson, Adam Entsminger, Jingsong Chen
Estimating the term…
The present invention provides demineralized bone fibers exhibiting optimal handling properties (e.g., high moldability and low elastic modulus) and biological activities (e.g., osteoinductivity) as well as non-demineralized bone fibers useful for preparing the demineralized bone fibers. A well-controlled demineralization process for preparing the demineralized bone of fibers is also provided. Products comprising the demineralized bone fibers and uses thereof are further provided.
A method for preparing a demineralized bone graft, wherein the demineralized bone graft has a residual calcium content of less than 6 wt % based on the dry weight of the demineralized bone graft, comprising subjecting a non-demineralized bone graft to a single incubation in an acid solution for no more than 300 seconds, wherein the acid solution has a pH of 0-4.
12-13. (canceled)
A composition comprising demineralized bone fibers having a residual calcium content of less than 6 wt % based on the dry weight of the demineralized bone fibers, wherein the demineralized bone fibers are osteoinductive, and wherein the demineralized bone fibers have an elastic modulus of less than 100.00 kPa.
16-21. (canceled)
23-24. (canceled)
26-27. (canceled)
29-32. (canceled)
A composition comprising demineralized bone fibers having a residual calcium content of between 0.5-6 wt % based on the dry weight of the demineralized bone fibers, wherein the demineralized bone fibers are osteoinductive, wherein the demineralized bone fibers have a specific surface area of at least 100 cm2/g.
37-39. (canceled)
Dependencies are inferred from the claim text.