US 2019/0314546 A1 · ANTIBIOTIC POLYMETHYLMETHACRYLATE BONE CEMENT

Abstract

An antibiotic polymethylmethacrylate bone cement that is composed of methylmethacrylate, at least one polymethylmethacrylate or a polymethylmethacrylate-copolymer, at least one polymerisation initiator, such as in radical initiator, at least one polymerisation accelerator, and at least one radiopaquer, whereby the components are present in a powdered component and a liquid monomer component or in two components that are pasty at room temperature. The polymethylmethacrylate bone cement comprises the cyclical lipopeptide, daptomycin, a pharmacologically tolerable salt of daptomycin, a solvate and/or a hydrate containing daptomycin and at least one calcium salt, which preferably comprises at least two different release profiles. The bone cement is useful in one-stage or two-stage septic revision surgery.

Claims29

Dependent claims

A method of conducting a one-stage or two-stage septic revision surgery, said method comprising anchoring a revision articular endoprosthesis in an area within the human body with an antibiotic bone cement, wherein the antibiotic bone cement is prepared by polymerizing an antibiotic polymerizable bone cement comprising:

(i) at least one monomer for radical polymerisation;
(a2) at least one organic polymer comprising at least one polymethylmethacrylate and/or one polymethylmethacrylate-copolymer, and
(iii) at least one polymerisation initiator;
(iv) at least one radiopaquer;
wherein
the antibiotic polymerizable bone cement comprises,
(v) as component 1, daptomycin, a pharmacologically tolerable salt of daptomycin, a polymorphous form of daptomycin, a solvate and/or a hydrate containing daptomycin;
and
(vi) at least one calcium salt.

6 more elements

A method of conducting a one-stage or two-stage septic revision surgery, said method comprising removing an infected articular endoprosthesis from an area within the human body and temporarily introducing a spacer into that area, wherein the spacer is composed of an antibiotic bone cement prepared by polymerizing an antibiotic polymerizable bone cement comprising:

(i) at least one monomer for radical polymerisation;
(a2) at least one organic polymer comprising at least one polymethylmethacrylate and/or one polymethylmethacrylate-copolymer;
and
(iii) at least one polymerisation initiator;
(iv) at least one radiopaquer;
wherein
the antibiotic polymerizable bone cement comprises,
(v) as component 1, daptomycin, a pharmacologically tolerable salt of daptomycin, a polymorphous form of daptomycin, a solvate and/or a hydrate containing daptomycin;
and
(vi) at least one calcium salt.

7 more elements

Dependencies are inferred from the claim text.

Antibiotic polymethylmethacrylate bone cement

Life of this patent

Antibiotic polymethylmethacrylate bone cement

Life of this patent

Abstract

Claims29