Synthetic adenoviruses targeting bone tissue and uses thereof
AssigneeThe Salk Institute for Biological Studies
InventorsClodagh O'Shea, Colin Powers, Lei Zhang
Life of this patent
Estimating the term…
Abstract
Synthetic adenoviruses with tropism to bone tissue are described. The synthetic adenoviruses include an adenovirus type 11 (Ad11) fiber protein or a chimeric adenovirus fiber protein having an Ad11 knob domain. The synthetic adenoviruses can also include a transgene, such as a reporter gene or a transgene encoding a factor that promotes bone regeneration or repair. Use of the synthetic adenoviruses to target bone tissue and/or to promote bone repair or regeneration is also described.
Claims20
A method of expressing a transgene in bone tissue of a subject, comprising administering to the subject a synthetic adenovirus comprising:
- the transgene;
- and
- a fiber protein from adenovirus serotype 11 (Ad11), or a chimeric fiber protein having an Ad11 knob domain.
A method of promoting bone repair or regeneration in a subject, comprising administering to the subject a synthetic adenovirus comprising:
- a transgene encoding a factor that promotes bone repair or regeneration;
- and
- a fiber protein from adenovirus serotype 11 (Ad11), or a chimeric fiber protein having an Ad11 knob domain.
A synthetic adenovirus genome, comprising a nucleotide sequence at least 95% identical to SEQ ID NO:
- 2 or SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.