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US 2019/0314524 A1Published application
Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids
AssigneeAcuitas Therapeutics, Inc.
InventorsSteven M. Ansell, Xinyao Du
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Abstract
Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
Claims36
A compound having the following structure (IF):
- or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:
- G1 and G2 are each independently unsubstituted C1-C12 alkylene or C1-C12 alkenylene;
- G3 is C1-C24 alkylene, C1-C24 alkenylene, C3-C8 cycloalkylene;
- or C3-C8 cycloalkenylene;
- R1 and R2 are each independently branched C6-C24 alkyl;
- R3 is H, OR5, CN, —C(═O)OR4, —OC(═O)R4 or —NR5C(═O)R4;
- R4 is C1-C12 alkyl;
- and
- R5 is H or C1-C6 alkyl.
6 more elements
2-5. (canceled)
11-12. (canceled)
Dependencies are inferred from the claim text.