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US 2019/0314520 A1Published application
Carrier Nanoparticles And Related Compositions, Methods And Systems
AssigneeCalifornia Institute of Technology
InventorsMark E. Davis, Akinleye Alabi
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Abstract
Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid and a linkage cleavable under reducing conditions, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.
Claims29
A nanoparticle comprising a polymer containing a polyol comprising one or more of at least one of the following structural units of Formula (I), (II), or (III):
- wherein:
- A comprises a polyol having 4 or 6 adjacent hydroxyl groups;
- and
- B comprises a neutral, cationic, or anionic organic moiety having a chemical backbone comprising —CmH2m— linkages, where m≥1, and optionally one or more:
- (a) polyglycol linkage, —(CH2—CH2—O)p—, in the chemical backbone, where p is from 20 to 200;
- and/or
- (b) amidinium, quaternary ammonium, or imidazolium functional group in the chemical backbone;
- and/or
- (c) sulfonate, nitrate, carboxylate, phosphonate, or primary or secondary amine bonded to the chemical backbone;
- and
- wherein A and B are covalently linked by amide or ester linkages.
8 more elements
Dependencies are inferred from the claim text.