Back to results
US 2019/0314514 A1Published application
Kidney-Targeted Drug Delivery Systems
AssigneeUniversity of Mississippi Medical Center
InventorsAlejandro R. Chade, Gene L. Bidwell, III
Life of this patent
Estimating the term…
Abstract
A composition including an elastin-like polypeptide (ELP) coupled to a kidney targeting peptide and a therapeutic agent is provided.
Claims20
A pharmaceutical composition, comprising:
- a therapeutically effective amount of elastin-like polypeptide (ELP) coupled to a therapeutic agent, the ELP including an amino acid sequence having between 5 and 320 repeats of the amino acid sequence GVPGX (SEQ ID NO:
- 1);
- and
- a pharmaceutically acceptable carrier;
- wherein X in the sequence GVPGX (SEQ ID NO:
- 1) is any amino acid except proline;
- and
- wherein the therapeutically effective amount of the ELP coupled to the therapeutic agent improves the deposition and retention of the therapeutic agent mostly in the renal cortex relative to a non-conjugated therapeutic.
5 more elements
A method of treating kidney disease in a subject in need thereof, comprising:
- administering to the subject an effective amount of a pharmaceutical composition comprising an elastin-like polypeptide (ELP) coupled to a therapeutic agent, and a pharmaceutically acceptable carrier;
- wherein the ELP includes between 5 and 320 repeats of the amino acid sequence GVPGX (SEQ ID NO:
- 1);
- wherein X in the sequence GVPGX (SEQ ID NO:
- 1) is any amino acid except proline;
- and
- wherein the composition accumulates mostly in the renal cortex.
4 more elements
Dependencies are inferred from the claim text.