P53 degradation inducing molecule and pharmaceutical composition
AssigneeTokyo University of Science Foundation
InventorsEtsuko MIYAMOTO, Masaaki OZAWA
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Abstract
A p53 degradation inducing molecule which can induce degradation of p53 proteins or p53 composites, and a pharmaceutical composition containing said p53 degradation inducing molecule are provided. This p53 degradation inducing molecule is a conjugate of a p53 affinity molecule which has affinity for p53 proteins or p53 composites, and a proteolysis induction tag which has affinity for protease and which does not inhibit proteolysis of proteins by protease.
Claims10
A p53 degradation inducing molecule being a conjugate of a p53 affinity molecule that has an affinity with a p53 protein or a p53 complex, and a protein-degradation inducing tag that has an affinity with a protease and does not inhibit degradation of a protein by the protease;
- and being capable of inducing degradation of the p53 protein or the p53 complex.
Dependencies are inferred from the claim text.