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US 2019/0314495 A1Published application
Allergen desensitization method
AssigneesDBV Technologies, Assistance Publique-Hopitaux de Paris, Universite Paris Descartes
InventorsChristophe DUPONT, Pierre-Henri BENHAMOU, Bertrand DUPONT
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Abstract
The present application relates to a method for desensitization of allergic patients. More specifically it relates to an epicutaneous desensitization method, applicable to any type of allergens and of patients. The method of the invention is essentially non-invasive and does not require the use of adjuvants. Further, it may be easily applied and monitored by the actual patient.
Claims14
A method for epicutaneous desensitization of a subject allergic to milk, the method comprising:
- a) determining a dose of a milk allergen which causes an immune reaction on the skin of the subject upon epicutaneous application thereof;
- b) epicutaneously exposing the subject to the milk allergen and generating the immune reaction in the subject by applying said dose of the milk allergen, without an adjuvant, onto an intact region of skin of the subject;
- and
- c) repeatedly applying the milk allergen, without an adjuvant, to an intact region of the skin of the subject, at a dose, frequency or for an application time adapted to sustain the immune reaction, the exposure and sustained reaction leading to desensitization of the subject;
- wherein the milk allergen is applied by a cutaneous occlusive device configured to ensure contact between the allergen and the region of skin, and wherein said dose of milk allergen is comprised between 0.1 and 1,000 μg/cm2 of a surface area of the device.
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Dependencies are inferred from the claim text.