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AssigneeNovavax, Inc.
InventorsSarathi BODDAPATI, Anushree HERWADKAR, Jason WONG, Yen-Huei LIN, Gale SMITH, Jing-Hui TIAN
Estimating the term…
Disclosed herein are multivalent nanoparticle vaccine compositions suitable for use in influenza vaccines. The nanoparticles include effective amounts of influenza glycoproteins that provide increased immune responses compared to a commercially available influenza vaccine composition. The present disclosure also provides vaccine formulation strategies that are cost effective and are convenient for clinical use. Methods of administering the nanoparticle vaccine compositions to a subject are also disclosed.
A multivalent immunogenic influenza composition comprising
The composition of claim 6, wherein the Matrix M contains Fraction A Matrix and Fraction C Matrix (85:15;
A HaSMaN (Hemagglutinin Saponin Matrix Nanoparticle) comprising an ISCOM matrix particle and recombinant influenza HA glycoprotein trimers, wherein the HA glycoprotein is from a Type A influenza strain, wherein the HA glycoprotein tail is associated with the particle and wherein the HA glycoprotein head extends distally from the particle.
A method of preparing a HaSMaN comprising combining a detergent core nanoparticle with a saponin-based matrix adjuvant.
Dependencies are inferred from the claim text.