Influenza hemagglutinin protein vaccines
AssigneeMerck Sharp & Dohme Corp.
InventorsJessica Anne Flynn, Lan Zhang, Kerim Babaoglu, Arthur Fridman, David Nickle
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Abstract
The disclosure relates to influenza virus hemagglutinin protein and DNA vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
Claims32
An influenza virus vaccine, comprising at least one isolated antigenic polypeptide:
- wherein the at least one antigenic polypeptide comprises an amino acid sequence that has at least 90% identity to a mature amino acid sequence in any one of SEQ ID NOs:
- 1-4, 8-11, 14-19, 41-61, and 83-88.
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An influenza virus vaccine comprising two isolated antigenic polypeptides, wherein the first polypeptide comprises an amino acid sequence that has at least 90% identity to the mature amino acid sequence of any one of SEQ ID NOs:
- 1-5, 8-11, 14-19, 41-63, and 83-88 and the second polypeptide comprises an amino acid sequence that has at least 90% identity to the mature amino acid sequence of SEQ ID NO:
- 20.
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Dependencies are inferred from the claim text.