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US 2019/0314472 A1Published application
Immune modulation for the treatment of age-related macular degeneration
AssigneeEnzo Biochem, Inc.
InventorsRobert Nussenblatt, Baoying LIU, Lai Wei, Elazar RABBANI, James J. DONEGAN
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Abstract
The invention provides methods for treating age-related macular degeneration by administering (i) peptide compositions, (ii) regulatory T-cells from the patient or a compatible donor, or (iii) a combination of regulatory T-cells and said peptide compositions. Also provided are methods for diagnosing age-related macular degeneration and monitoring its progression.
Claims4
A pharmaceutical composition, comprising
- a synthetic peptide which is GEPIPVTVDVTNNTEKTVKK (SEQ ID NO:
- 2) or VTVDVTNNTEKTVKK (SEQ ID NO:
- 3);
- and
- one or more of high molecular weight hyaluronic acid;
- IL-2;
- IL-15;
- TGF-β;
- all-trans retinoic acid;
- rapamycin;
- anti-CD3 antibodies;
- anti-CD28 antibodies;
- vitamin D3;
- dexamethasone;
- IL-10;
- indoleamine 2,3-dioxygenase;
- FTY720;
- a sphingosine kinase 1 inhibitor;
- cholera toxin B subunit;
- ovalbumin;
- Flt2L;
- anti-thymocyte globulin;
- and CTLA-4/Ig.
20 more elements
Dependencies are inferred from the claim text.