Methods of treating hormonal disorders associated with androgen deficiency using a repeat microflare dosing regimen

Abstract

A method of treating a hormonal disorder associated with androgen deficiency is disclosed. The method includes administering a therapeutically effective dose of a composition having a GnRH agonist to a subject in need thereof. The therapeutically effective dose is sufficient to support a first flare of hormones. The method further includes allowing a time interval after the administration of the dose. The time interval is sufficient to support pituitary-gonadal axis recovery. The method further includes administering at least one subsequent dose of the composition to the subject after the time interval. The subsequent dose is sufficient to support a microflare of hormones that is less than, or equal to, a magnitude of the first microflare. Subsequent doses spaced by the time interval resulting in a repeat microflare sufficient to chronically elevate hormone levels and provide relief of signs or symptoms of androgen deficiency.

Dependencies are inferred from the claim text.