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US 2019/0314456 A1Published application
Methods of using interleukin-10 for treating diseases and disorders
AssigneeArmo Biosciences, Inc.
InventorMartin OFT
Life of this patent
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Abstract
Methods of treating subjects having a disease or disorder responsive to IL-10, including methods of administration and dosing regimens associated therewith, are provided.
Claims9
1-99. (canceled)
A method of treating a solid tumor in a human subject, comprising:
- administering to a human subject a PEG-IL-10 agent at 5-20 μg/kg daily by parenteral injection,
- wherein the PEG-IL-10 agent comprises amino acid residues 19-178 of SEQ ID NO:
- 29,
- wherein the PEG-IL-10 agent is a mixture of mono-pegylated and di-pegylated IL-10,
- and wherein the PEG component of the PEG-IL-10 agent has a molecular mass of about 5 kDa, and the PEG component is covalently attached to the alpha amino group of the amino acid residue at the N-terminus of IL-10.
2 more elements
Dependencies are inferred from the claim text.