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US 2019/0314455 A1Published application
Cytokine conjugates for the treatment of proliferative and infectious diseases
AssigneeSynthorx, Inc.
InventorsJerod PTACIN, Carolina E. CAFFARO, Marcos MILLA
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Abstract
Disclosed herein are interleukin (IL) conjugates (e.g., IL-2 conjugates) and use in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).
Claims20
A modified interleukin-2 (IL-2) polypeptide comprising:
- a. at least one unnatural amino acid;
- and
- b. a conjugating moiety covalently attached via a linker to the at least one unnatural amino acid;
- wherein the conjugating moiety is a water-soluble polymer, a lipid, a protein, or a peptide, wherein the at least one unnatural amino acid is located in region 35-107, wherein the region 35-107 corresponds to residues K35-Y107 of SEQ ID NO:
- 1, and wherein the modified interleukin-2 (IL-2) polypeptide comprises at least 80% sequence identity to SEQ ID NO:
- 1.
3 more elements
Dependencies are inferred from the claim text.