Peptide for repairing cartilage and treating osteoarthritis
AssigneeGuangzhou Link Health Pharma Co., Ltd.
InventorsYan SONG, Yuansheng XU, Xiaoyu LU
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Abstract
A BM23 peptide is obtained by mutating and modifying BMP-2. The BM23 peptide improves stability and duration of in-vivo efficacy relative to BMP-2, has an activity of promoting the differentiation of bone marrow mesenchymal stem cells into chondrocytes and promoting the proliferation of chondrocytes and can be used for repairing cartilage and/or treating osteoarthritis.
Claims20
A peptide, comprising 23 amino acids, wherein a sequence of the peptide is as shown in (SEQ ID NO:
- 1, wherein the 1st amino acid of the sequence is D-glutamine, the 7th amino acid of the sequence is homoarginine, and the 23rd amino acid of the sequence is amidated leucine.
A pharmaceutically acceptable salt of a peptide, comprising:
- acetates, hydrochlorides, phosphates or acetates, wherein the peptide comprises 23 amino acids, a sequence of the peptide is as shown in SEQ ID NO:
- 1, the 1st amino acid of the sequence is D-glutamine, the 7th amino acid of the sequence is homoarginine, and the 23rd amino acid of the sequence is amidated leucine.
A drug, comprising a peptide at a therapeutically effective dose and a pharmaceutically acceptable carrier, wherein the peptide comprises 23 amino acids, a sequence of the peptide is as shown in SEQ ID NO:
- 1, the 1st amino acid of the sequence is D-glutamine, the 7th amino acid of the sequence is homoarginine, and the 23rd amino acid of the sequence is amidated leucine.
Dependencies are inferred from the claim text.