Treatment of degenerative joint disease

A method of treating joint pain in a human comprising administering to a joint of the human selected from the group consisting of a shoulder joint, a hand joint and a spinal joint, an intra-articular injection of an effective amount of a pharmaceutical composition comprising DA-DKP prepared by removing albumin from a solution of a human serum albumin composition.

A method of treating joint pain in a human comprising administering to a joint of the human selected from the group consisting of a shoulder joint, a hand joint and a spinal joint, an intra-articular injection of an effective amount of a pharmaceutical composition comprising DA-DKP at a concentration of from 50 μM to 350 μM prepared by passing the human serum albumin composition over an ultrafiltration membrane with a molecular weight cut off that retains the albumin, and wherein the resulting filtrate comprises DA-DKP.

A method of treating osteoarthritis in a human comprising administering to a joint of the human selected from the group consisting of a shoulder joint, a hand joint and a spinal joint, an effective amount of a pharmaceutical composition comprising DA-DKP prepared by removing albumin from a solution of a human serum albumin composition.