Cancer Treatment and Diagnosis

A method for treating cancer in a human subject, the method comprising the steps of:

• isolating a sample from a human subject having cancer;
• determining the functional activity of cGAS in the sample;
• selecting a therapy for the cancer based on the functional activity of the cGAS in the sample, and
• administering the selected therapy to the subject.

A method for treating cancer comprising

• a) administering a viral oncolytic therapy to a subject,
• b) determining the level of STING or cGAS in a sample from the subject, wherein a decrease in STING or cGAS activity is predictive of a positive outcome of oncolytic therapy, and
• c) i) if levels of STING in the subject are low, continuing oncolytic therapy;
• or
• ii) if STING or cGAS levels are normal or partially active, discontinuing viral oncolytic therapy and/or administering a second agent that can increase STING levels in the subject in order to improve the outcome of the viral oncolytic therapy.