Methods for promoting healing of tissue

A method for promoting healing of tissue in a subject, the method comprising:

• delivering a bioreactor into a subject, the bioreactor comprising an enclosed housing and paracrine factor producing cells enclosed within the housing, the housing being impermeable to the paracrine factor producing cells, impermeable to immunological cells outside of the housing, and permeable to paracrine factors produced by the paracrine factor producing cells;
• and
• wherein the paracrine factors produced by the paracrine factor producing cells are released out of the housing to promote healing of the tissue.

A method for promoting healing of tissue in a subject, the method comprising:

• percutaneously delivering a bioreactor into the subject, the bioreactor being mounted on a catheter having at least one lumen and an infusion port, the catheter lumen connecting the infusion port with the housing lumen, the bioreactor comprising an enclosed housing having a lumen, and said housing having pores of sufficient size to restrict the entry of immunological cells into the housing, restrict the egress of cells out of the housing, and allow the release of paracrine factors out of the housing;
• and
• introducing cells through the infusion port and into the housing lumen permitting the release of paracrine factors out of the housing to promote healing of the tissue.