Methods for treating gi tract disorders
AssigneeNeurogastrx, Inc.
InventorsCyril De Colle, Pankaj Pasricha
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Abstract
Provided herein are methods, compositions, and kits for the treatment of an enteric nervous system disorder. Such methods may comprise administering to a subject an effective amount of a phenothiazine compound, a peripherally restricted dopamine decarboxylase inhibitor, and/or a peripherally restricted dopamine D2 receptor antagonist that does not substantially inhibit hERG channels.
Claims4
A method of treating an enteric nervous system disorder in a human subject in need thereof, comprising administering to the subject an effective dose of a compound comprising a phenothiazine group or a pharmaceutically acceptable salt, solvate, or metabolite thereof to the subject for over 5 days.
A method of treating an enteric nervous system disorder in a subject in need thereof, comprising administering to the subject an effective dose of a compound comprising a phenothiazine group or a pharmaceutically acceptable salt, solvate, or metabolite thereof to the subject for over 7 days.
A method of treating an enteric nervous system disorder in a subject in need thereof, comprising co-administering to the subject an effective dose of a compound comprising a phenothiazine group or a pharmaceutically acceptable salt, solvate, or metabolite thereof, and a dopamine decarboxylase inhibitor.
4-45. (canceled)
Dependencies are inferred from the claim text.