Pyrimidine compounds containing acidic groups

A compound having the structure of Formula (1), or a pharmaceutically acceptable salt thereof,

• wherein
• R1a is selected from the group consisting of H, C1-C4 alkyl, —NH2, —NHAc, —COOH, —SO2CH3, —SCH3, —OCH3, and
• wherein the alkyl is optionally substituted with —OH, —NH2, —NHAc, —COOH, —SO2CH3, —SCH3, —OCH3,
• or A;
• R1b is C2-C5 alkyl;
• X is selected from the group consisting of H and C1-C4 alkyl, wherein the alkyl is optionally substituted with A, —OH, or —C(CH3)2OH;
• L1 is selected from the group consisting of a bond, —CH2—, —CF2—,
• —O—, —S—, —SO2—, —NH—, and —CH2CH2—;
• Y is selected from the group consisting of C1-C3 alkyl, aryl, and heteroaryl, wherein the alkyl, aryl, and heteroaryl are optionally substituted with 1-5 substituents that are independently selected from A, C1-C3 alkyl, and C1-C3 alkoxy;
• A is selected from the group consisting of
• L2 is selected from the group consisting of a bond, —(CH2)n—, —C(O)NH(CH2)n,
• —[O(CH2CH2)]n—, —[O(C1-C4 alkylene)]-, —[O(CH2CH2)]n—OCH2CH2CF2—;
• —C(O)NHCH2CH2—[O(CH2CH2)]m—;
• and —C(O)NHCH2CH2—[O(CH2CH2)]m—OCH2CH2CF2—;
• m is an integer from zero to four;
• n is an integer from one to four;
• wherein the compound is substituted with at least one A;
• and
• when X is —CH3;
• L1 is —CH2—;
• Y is aryl substituted with A;
• and L2 is —CH2—;
• then A is not -L2-COOH, except when R1a comprises —COOH or —SO2CH3;
• and
• when X is —CH3;
• L1 is —CH2—;
• Y is aryl substituted with A;
• L2 is —CH2—, —O—(CH2)2—O(CH2)2—, or —O—(CH2)2—O(CH2)2(CF2)—;
• and A is
• then A and L1 are not in a para position with respect to each other.