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AssigneeAcerta Pharma B.V.
InventorsBrian Lannutti, Todd Covey, Allard Kaptein, Dave Johnson, Jay Stamatis, Cecile M. Krejsa, John Gregory Slatter
Estimating the term…
In an embodiment, therapeutic methods and uses of Bruton's Tyrosine Kinase (BTK) inhibitors for treatment of cancer, inflammation, immune disorders, and autoimmune disorders, including dermatoses, and for transplantation prophylaxis, based on BTK occupancies and/or BTK resynthesis rates for B cells in various diseases, tissue compartments, including bone marrow and lymph nodes, are described. In an embodiment, dosing regimens for a BTK inhibitor for treatment of cancer, inflammation, immune disorders, and autoimmune disorders, including dermatoses, and for transplantation prophylaxis, based on BTK occupancies and/or BTK resynthesis rates for B cells in various diseases, tissue compartments, including bone marrow and lymph nodes, are described.
1-85. (canceled)
A method of treating Waldenstrom's macroglobulinemia in a human comprising administering to the human a therapeutically effective amount of a compound of Formula (II):
Dependencies are inferred from the claim text.