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US 2019/0314335 A1Published application
Lipid particle composition and pharmaceutical composition
AssigneeFUJIFILM Corporation
InventorsYuta YOSHINO, Hayato OGURA, Mikinaga MORI, Taisuke ENDO, Kentaro NUMAJIRI, Ritsuko HORI
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Abstract
An object of the present invention is to provide a lipid particle composition containing panobinostat or a salt thereof and exhibiting a high bone marrow-targeting capability, and a pharmaceutical composition including the lipid particle composition. According to the present invention, provided is a lipid particle composition containing panobinostat or a salt thereof, in which a lipid particle contains a phospholipid and cholesterol.
Claims17
A lipid particle composition comprising:
- panobinostat or a salt thereof,
- wherein a lipid particle contains a phospholipid and cholesterol.
A lipid particle composition comprising:
- panobinostat or a salt thereof,
- wherein an area ratio represented by Formula 1 up to infinite time after single administration of a lipid particle composition of 4 mg/kg as a panobinostat amount to a tail vein of a mouse is 5 or more.
- (area under bone marrow concentration-time curve)/(area under gastrointestinal tract concentration-time curve) Formula 1:
Dependencies are inferred from the claim text.